Click to enlarge Anne's weekly pic.


Decisions about whom to mate with can sometimes be difficult, but making the right choice is critical for an animal's reproductive success. The ubiquitous fruit fly, Drosophila, is clearly very good at making these decisions. Upon encountering another fly, a male may or may not choose to court. He estimates his chances of success primarily on the basis of pheromone signals and previous courtship experience. The female decides whether to accept or reject the male, depending on her perception of his pheromone and acoustic signals, as well as her own readiness to mate. This simple and genetically tractable system provides an excellent model to explore the neurobiology of decision making.Ah, yes, mating decisions. We all know about that. We all have our pheromones, hormones, wiggle dances and courtship songs. Dickson gives us a sweet little diagram of Drosophila courtship (click to enlarge). The outcome? Yes or no? Home base or strike out? It's like the cover of Cosmo for fruit flies.

This new feeling has not changed me, has not made me happy and enlightened all of a sudden, as I had dreamed, just like the feeling for my child. There was no surprise in this either. Faith -- or not faith -- I don't know what it is -- but this feeling has come just as imperceptibly through suffering, and has taken firm root in my soul.Let Levin learn, as we have learned, about our genetic predispositions to certain behaviors, fidelity, for example, or impetuosity. Let him catch a vision, as we have caught a vision, of the myriad biochemical nudgings and tuggings that cause us to act one way or another. Will this new knowledge of the genetics of behavior change the moral circumstances of his life?
I shall go on in the same way, losing my temper with Ivan the coachman, falling into angry discussions, expressing my opinions tactlessly; there will be still the same wall between the holy of holies of my soul and other people, even my wife; I shall still go on scolding her for my own terror, and being remorseful for it; I shall still be as unable to understand with my reason why I pray, and I shall still go on praying; but my life now, my whole life apart from anything that can happen to me, every minute of it is no more meaningless, as it was before, but it has the positive meaning of goodness, which I have the power to put into it.
Genes do not specify behavior directly but rather encode for molecular products that build and govern the functioning of the brain through which behavior is expressed. Brain development, brain activity, and behavior all depend on both inherited and environmental influences, and there is increasing appreciation that social information can alter brain gene expression and behavior. Furthermore, variation in behavior shapes the evolution of genomic elements that influence social behavior through the feedback of natural selection.In other words, as a species we are what we are at least partly because of what we have been, and what we will become is a least partly determined by what we are.
There are many levels of neural and neuroendocrine regulation that lie between the genome and a social behavior, including transcription, translation, posttranslational modifications, epigenetic changes, brain metabolism, neural (electrochemical) activity, and neuromodulation. Moreover, this regulation occurs in complex and dispersed temporal and spatial patterns within the brain, over physiological time, developmental time, and throughout an individual's life. The study of social behavior adds an additional tier of complexity because it depends on interactions and communication among individuals. In most cases, social behavior must be studied in a natural context in which the full repertoire of environmental influences and behaviors are expressed.Which is to say, we are wonderfully complex molecular machines in interaction with an almost infinitely variable environment. In the next few decades we'll be learning a lot more about the genetic and environmental roots of behavior. None of this will change the perennial dynamics of trying to live an ethical life. A complete transcription of Anna Karenina's genome would not change a whit the worth of her story.
"Can you get sustained quantum coherent behavior at body temperature in something like neurons? Nobody knows."Well, yes, it may be true. And the existence of a supernatural personal God may be true too. Whatever self-organization and emergence might be, for the time being they are not science. As I wrote in the earlier post: "Sometimes Kauffman's speculations sound like a kind of pervasive, built-in 'intelligent design' -- a stealth supernaturalism, or at best a resurgent vitalism."
"The mathematics [of self-organization] has been proved, but it still needs to be shown experimentally."
"Yet a number of physicists, including Nobel laureates Philip Anderson and Robert Laughlin, feel that reductionism is not adequate to understand the real world. In its place, they talk about "emergence." I think they're right."
"Maybe the mind is acausal. Maybe the mind is non-algorithmic. I don't want you to take this very seriously. It's just Stu Kauffman getting old and thinking weird things. But it may be true."
I have been reading David Bain's Empire Express, an account of the building of the first transcontinental railroad. Part of the fun was using Google Earth to trace the course of the tracks. I started at Donner Pass in the High Sierras (where a new and longer summit tunnel seems to have replaced the original) and spent several enjoyable hours tracing the railroad west to Sacramento and east to Council Bluffs. It gave me an appreciation of the scale of the achievement that the maps in the book could never do.Look, I want to love this world
as though it's the last chance I'm ever going to get
to be alive
and know it.

When I read Eliade, the realization that struck me was his observation that in modernity we are no longer religious in the sense he used that word, that the world to us is homogenous, that we no longer divide the world, space or time, into sacred and profane. We have inherited ways and language from our religious ancestors, but they have lost their meanings. At most what we call religious today is nostalgia. It is sentiment. It is sorrow.This strikes me as exactly right. My response has generally been that certain emotions we call religious are very likely part of our evolved biological nature. What emotions? Awe. A sense that there is something afoot in the world that we do not fully understand, something deep and mysterious that is worthy of attention, celebration. A cosmic humility.
It seems like the greater challenge you face is not defending religious naturalism from claims that it is a supernatural belief. Instead, the challenge is to show that the word "religious" means something more than nostalgia. That is what any of us face who use the word "religious."
Leonardo da Vinci. Niccolo Machiavelli. Desiderius Erasmus. Nicolaus Copernicus. Martin Luther. John Calvin. Francis Bacon. Thomas Hobbes. Rene Descartes. Blaise Pascal. John Locke. Isaac Newton. Voltaire. Jean Jacques Rousseau. Adam Smith. Immanuel Kant. Jeremy Bentham. Mary Wollstonecraft. Thomas Robert Malthus. Georg Wilhelm Friedrich Hegel. Robert Owen. Karl Maria von Clausewitz. George Perkins Marsh. Charles Robert Darwin. Karl Marx. Michael Bakunin. William James. Friedrich Wilhelm Nietzsche. Ivan Petrovich Pavlov. James George Frazer. Sigmund Freud. Mahandas Karamchand Gandhi. Albert Einstein. John Maynard Keynes. Ludwig Wittgenstein. Norbert Wiener and Warren McCulloch (who share an essay).Obviously, any such list is idiosyncratic and to some extent arbitrary. Why Pavlov, for example, and not Pasteur? Why Pascal and not Spinoza? Why Descartes and not Galileo? Why Bakunin and not Jefferson? Why Hobbes and not Hume? Why Marsh and not Thoreau? Why Wiener/McCulloch and not Shannon/von Neumann? Of course, any list today would be more inclusive by ethnicity and gender.


Protein kinases are enzymes that mediate cellular decision processes by catalyzing the addition of a negatively charged phosphate group to protein substrates, which can subsequently be recognized by phosphorylation-dependent binding domains in other proteins. The human genome encodes 518 protein kinases, which have been organized into a tree that represents evolutionary relationships. The substrate specificities of kinases are in part determined by the amino acid sequence of the phosphorylation sites, and comprehensively mapping the consensus sequence motif recognized by each kinase catalytic domain is thus crucial for understanding phosphorylation mediated signaling networks.I wish I knew enough biology to fully understand what's going on here, but one cannot look at the poster without grasping something of our evolutionary history, and indeed the marvelous complexity of what is going on in every cell of our bodies. The unraveling of the story of DNA to RNA to proteins to cellular chemistry is certainly the epic scientific story of my lifetime -- and there is more, much more, to come.


